The Engineer II (MTS) is a key member of the internal Manufacturing Technical Support (MTS) team, supporting critical activities within our manufacturing team to advance our RNAi technology. This is a lab-based position with a focus on general lab work, including conducting experiments and testing within our drug product and combination product (device) development labs. The Engineer II will execute experiments, perform in-process and final product testing, and support non-GMP manufacturing operations at our Cambridge development labs.

Key Responsibilities:

• Assist in the execution of development experiments.
• Provide laboratory organization support for general operations.
• Execute and document drug delivery device testing with guidance.
• Perform analytical in-process and final product testing for bulk drug product and drug product, including compendial methods, UPLC/HPLC, particle size analysis, and spectroscopy.
• Assist in coordinating routine and non-routine sample submissions, including receipt, aliquoting, inventory management, and shipping to external laboratories.
• Contribute to the creation and revision of technical documents (e.g., SOPs, protocols, reports).
• Support and contribute to method and equipment lifecycle activities, including implementation, qualification, validation, and maintenance.
• Assist management and team members with investigations, particularly in commercial manufacturing problem-solving.
• Support CAPA initiatives and continuous improvement efforts.

Accountabilities:

• Execution of routine laboratory experiments.
• Support for routine testing within communicated timelines.
• Continuous operation and maintenance of the MTS laboratory.
• Contributions to Manufacturing department and organizational goals.

Knowledge and Skills:

• Ability to work independently and manage multiple priorities.
• Strong teamwork, organizational, and communication skills.
• Capacity to adapt to changing priorities and fast-paced environments.

Physical/Environmental Factors:

• Must comply with all laboratory safety requirements.
• Ability to travel between Alnylam sites (Kendall, Alewife, and Norton) as needed.
• May be required to lift objects up to 50 lbs.

Education and Experience:

• Bachelor's degree in a relevant scientific field (e.g., biochemistry, chemistry, or other wet lab experience).
• Degree in engineering.
• Minimum 2 years of professional lab experience.
• Background in engineering, process development, or executing investigations in the lab (particularly related to commercial manufacturing problems).

Scope:

•  Location: Primary worksite is Cambridge, MA. The ability to commute to Norton as needed is required.
•  Work Schedule: Monday - Friday, 9:00 AM - 5:00 PM. No weekend work required.